Laboratory Question for the Week of January 16, 2023


Are there any changes to the NCCI policy manual for the molecular pathology section?


For 2023, one section .5 included some significant updates in bold below:

CPT® codes 81445, 81450, and 81455 describe targeted genomic sequence, DNA analysis, or combined DNA and RNA analysis. 81445 applies to solid organ neoplasm type (5-50 genes) and 81450 applies to hematolymphoid neoplasm type (5-50 genes), while 81455 applies to the number of genes analyzed for either a solid or hematolymphoid neoplasm (51 or greater genes). Providers/suppliers may not report 81455 with either 81445 or 81450. CPT codes 81449, 81451, and 81456 describe targeted genomic sequence RNA analysis using a separate method.

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