Question:

Can a physician’s interpretation of a molecular pathology procedure (such as in the CPT® code range 81161–81408) be reported with CPT code 88291 (cytogenetics and molecular cytogenetics, interpretation and report)?

Answer:

A physician’s interpretation of a molecular pathology procedure can be reported with HCPCS code G0452 when medically reasonable and necessary. It should not be reported with CPT code 88291 (cytogenetics and molecular cytogenetics, interpretation, and report).

Reporting requirements related to G0452 can be found in NCCI Manual for Medicare Services, Chapter X, Section L (Medically Unlikely Edits) at https://www.cms.gov/Medicare/Coding/NationalCorrectCodInitEd/index.html.

CPT® is a registered trademark of the American Medical Association.

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CPT® copyright 2024 American Medical Association (AMA). All rights reserved.

Fee schedules, relative value units, conversion factors and/or related components are not assigned by the AMA, are not part of CPT, and the AMA is not recommending their use. The AMA does not directly or indirectly practice medicine or dispense medical services. The AMA assumes no liability for data contained or not contained herein.

CPT is a registered trademark of the American Medical Association.

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