What guidance does the Centers for Medicare & Medicaid Services provide for tests on live tissue date of service (DOS)?


When a test is performed on live tissue for chemotherapy sensitivity, the DOS must be the date the test or service was performed only if:

  • The testing decision regarding the specific chemotherapy agent is made at least 14 days after discharge.
  • The specimen was taken while the patient was experiencing a hospital surgical procedure.
  • It is considered medically incorrect to collect the sample other than during the hospital procedure for which the patient was admitted.
  • The results of the test or service do not advise the treatment provided during the hospital stay.
  • The test or service was reasonable and considered medically necessary for treatment of an illness.

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