What are PLA codes?
Proprietary Laboratory Analyses (PLA) codes, established by the AMA CPT Editorial Panel in response to the Protecting Access to Medicare Act (PAMA) of 2014, are alphanumeric CPT® codes with a corresponding descriptor for labs or manufacturers that want to more specifically identify their testing. In its final rule for implementing PAMA, CMS defined advanced diagnostic laboratory tests (ADLTs) as tests developed and offered by a single lab that use a unique algorithm to analyze multiple DNA, RNA, or protein markers, and which provide new clinical diagnostic information that can’t be obtained by any other test. While PLA codes aren’t restricted to ADLTs and clinical diagnostic laboratory tests (CDLTs), as defined under PAMA, tests assigned to PLA codes must be performed on human specimens and must be requested by the manufacturer or clinical laboratory that offers the test. There are limiting factors that determine the appropriate use of the PLA CPT codes. Hence the name—proprietary laboratory analysis—for this code set.
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